Synergistic mediating effect of edible fungal polysaccharides (<i>Auricularia</i> and <i>Tremellan</i>) and <i>Crataegus</i> flavonoids in hyperlipidemic rats

Both edible fungal polysaccharides (Auricularia and Tremellan) Crataegus flavonoids promote the balance of dyslipidemia, which have a positive biological regulating effect on intestinal flora. In this study, extraction water-soluble from Auricularia Tremellan was investigated optimized firstly. Polysaccharides were then combined to study effects mediating role abnormal blood lipid concentration flora in vivo. The rats divided into 10 groups, NC (normal control), HM (model), PCI (Simvastatin PCII (Fenofibrate AAP auricular Polysaccharide), TFP (Tremella fuciformis HF (Crataegus Flavonoid), LDC (Low-dose combination), MDC (Medium dose HDC (High-dose used explore impact complex state lipid, liver, dyslipidemia rats. results showed that combination could significantly decrease levels triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), increase level high-density (HDL-C). It also decreased alanine aminotransferase (ALT) aspartate (AST) improved liver morphology. What is more, favorably alters microflora balance, promotes integrity mobility, inhibits growth harmful bacteria such as Escherichia coli/Shigella Clostridium compared with group. brief, had synergistic remission promoted health by improving metabolism, protecting tissue, hyperlipidemia